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A new study has identified a multi-omic biomarker for oral squamous cell carcinoma (OSCC) that can predict mortality in patients. The study, which used data from The Cancer Genome Atlas (TCGA) cohort and an internal cohort, found that a combination of epigenetic, gene expression, and histologic markers can differentiate between OSCC patients with different tobacco use histories. The researchers identified 3 epigenetic markers and 13 expression markers that are dysregulated in OSCC patients who were heavy smokers compared to those who never smoked. The study also found that the multi-omic biomarker, when combined with clinicopathologic factors, was highly predictive of mortality in OSCC patients. This new biomarker panel is the most accurate in predicting 5-year mortality in OSCC patients to date. The study's findings could have significant implications for the prognosis and treatment of OSCC patients.
